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DNA repair mechanism through Protein NEIL3 DNA, a nucleic acid which contain genetic information, used in the development and functioning of all known living organism and viruses. In this article we are going to discuss about NIEL3, a protein responsible for maintaining the integrity of DNA in Human and other mammals. Protein NIEL3 was first discovered in the year 2008 and since then it is considered as a basic DNA maintenance enzyme of type glycosylase. It functions as a maintenance protein by patrolling the strands of DNA, checking for lesions-places where one among the four DNA bases has been damaged by radiations or chemical activity. While patrolling if it finds any damaged bases, it cuts those damaged bases free from the DNA backbone also kicking off follow-on mechanisms that links in the proper undamaged bases. Looking at the importance of protein NEIL3 as maintenance protein, researchers and scientists took special interest in protein NEIL3 and came up with th...

TECHNOLOGY ENHANCING VACCINE EFFICIENCY: It is a well known fact that, for any pharma companies the most crucial and challenging issue is inventing a technology that can enhance the activity of vaccines. A paper published in Journal vaccine, 2008, by a company called Cure Lab, Inc. a Massachusetts based biotechnology company developed a new methodology for anti-viral vaccination. This vaccination technology comprises of two main components: The 1st component comprises of vaccine antigen that should be in two patterns. One should be easily processed inside the organism’s cells by an intracellular “chopping machine” called proteosome, while other element is resistant to “chopping”. According to the research published in Journal Vaccine, both these forms of an antigen would be used in combination to elicit a much stronger immune response than either of them would be able to do alone. With the invention of technology that could create a form of viral protein that could be eas...

LASERS IN DENTISTRY: Introduction: Laser is the acronym of ‘Light Amplification by Stimulated Emission of Radiation’. The first laser (ruby laser) was invented in 1960. Since then laser became one of the new effective technology in dental practice. It was first introduced as an alternative to the normal halogen curing light but now it has become the important instrument in many dental applications. This paper gives an insight on laser in dentistry. HISTORICAL REVIEW: Past ten years was a perfect example for clinical application of lasers in dental practice and an international attention has been given by the organizations to this technology. Laser was considered as a complicated technology with limited use in clinical dentistry, but now there is an increasing awareness of the use of lasers in the modern dental practice, where they are used as an alternative to already existing approaches. Its advancement in the field of dentistry is playing a major role in patient...

BREAST CANCER : KNOW FEW TIPS TO AVOID..! Breast cancer is one of the leading causes of death among women across the world. It is a type of cancer originating from breast tissue, most commonly from the inner lining of milk ducts or the lobules that supply the ducts with milk. Cancers originating from ducts are called as ductal carcinomas; those originating from lobules are known as lobular carcinomas. The disease occurs almost entirely in women, but men can get it, too. Worldwide, breast cancer comprises 22.9% of all cancers (excluding non-melanoma skin cancers) in women. Breast cancer is more than 100 times more common in women than breast cancer in men and more than 13% of the women have the risk of developing breast cancer at any age during her lifetime. “According to recent survey figures shows that, the number of new breast cancer cases is about 115,000 per year in India and the numbers expected to rise to 250,000 new cases per year by 2015 and also the survey fo...

NURSING SPECIALTIES AND CAREERS IN NURSING: Nursing is one of the most imposing profession in modern healthcare system and is essential to the future health care. The profession was believed lowly in many years back, how ever, with time and efforts from individuals like Florence Nightingale the perception of society has altered towards the nursing profession. Florence Nightingale was the legend, who had kick started the nursing profession, the legend who gave her life caring for the people those were sick, wounded and diseased. One of her biggest accomplishment was to raise nursing as profession to the level of a respectable profession for women. Florence Nightingale have got great influence over nursing profession in India and she made a close knowledge of Indian conditions, especially in army sector. She was interested in the running nursing operations for the civilian population, although her first interest was the welfare of the army in India. In 1865, Miss Florence Nig...

Scientific intelligence, biopharma primary / secondary research, competitive intelligence and regulatory intelligence professionals will benefit from cognizance of key trends in the biopharma industry. For an instance: recent investigation of the Indian drug market has gathered substantial attention, as India seems poised to turn a major player in the pharmaceutical segment worldwide. This report provides some key trends and predictions. BY 2020: INDIAN PHARMACEUTICAL INDUSTRY TO REACH $55 BILLION According to India Ratings, a Fitch company, the Indian pharmaceutical industry is estimated to grow at 20 % compound annual growth rate (CAGR) over the next 5 years. The Indian pharma industry, which is expected to grow over 15 % per annum between 2015 and 2020, will outperform the global pharma industry, which is set to grow at an annual rate of 5 % between the same period. Presently the market size of the pharmaceutical industry in India stands at US$ 20 billion. This level of grow...

Healthcare practices or systems in developed or high income countries especially United States of America (USA) are blighted by high and growing healthcare costs. To attain efficiency emerging countries like India, have put through thought processes that developed countries might be able to take up. This article depicts a few problems in healthcare delivery that India regularly confronts and how it sometimes deals those quandaries. This article also continues thought process about how the developed countries especially USA might use India’s working model to think differently about efficiency, still some of contexts dont use to developed countries. High Patient Volumes Vs Modernized clinical practice: Long waiting lines in busy outpatient department (OPD) is common, especially at primary healthcare or other government medical centres India, there are many hospitals in which a cardiologist confront as many as patients (close to 100 ) in their first half of their day. Suppose what...

Pain Management by Physiotherapist: Pain is unpleasant sensory and emotional experience with actual or potential tissue damage or described in terms of such damage. Pain is a major symptom in many medical conditions, the pain can significantly interfere with a persons quality of life and general functioning. Pain medicine is a sub-specialty of Rehabilitation Medicine, Neurology, Palliative Medicine and Psychiatry. Scientists have been trying for decades to know the mystery of pain. An important break through came in the mid 1960 when scientists discovered that brain could change or modulate the nervous system in response to pain. What normally occurs is that pain begins when the nociceptors (Pain Carrying Fibers). These are small thin fibers located through out body in peripheral nerve they release a bath of chemicals to carry pain message to brain. The study of pain in recent years attracted the physiotherapy. Pain is a major problem in our country as anywhere else but lack of...

VERTICAL FARMING, THE FUTURE OF FARMING: Have you ever thought, what could happen if there is no or few land left for farming? Answer would definitely be, deficiency of food. Yes, due to this deficiency of food substances, people may compete with each other and as per Charles Darwin theory “Only survival of the fittest” will be observed, leading a big question mark on the peaceful existence of Human race. It is been estimated that by the end of 2050, near to 80% of the earth’s population will reside in urban centers. It is also been estimated that, by employing the conservative estimates to present demographic trends, the human population will be increased by about 3 billion people during the interim. As per the analysis conducted by FAO and NASA, 109 hectares of fresh land is required to cultivate crops in order to balance the food requirement, through traditional farming practices as they are practiced today. At present, around 80% of the land present in earth’s surface is ...

QA is a good practice in the manufacture of bio, pharmaceutical products, as it is the process of ensuring for integrity of products to meet the regulatory standards for the proposed indication or proposed use. It is a responsibility that guarantees manufacturers meet the requirements of patients in terms of safety, quality, efficacy, strength, stability and reliability. Drug Industry vs. Quality assurance department The spate of counterfeit, inferior /adulterated medicines is a serious concern in the industry. The biopharma segment interpreted an increase in regulations after the thalidomide disaster in 1957. The rigorous, in-depth, scientific, systematic and sustainable move towards to commercial pharmaceutical manufacturing ensures protection of public health. The arrangement of specifications and practice control assesses in the industry, easily denoted as standard operating procedures (SOPs) that are formulated by drug regulatory agencies and scientific community to en...

Forward Thinking: Medical care profession is in the thick of a striking point of a qualitative change as external and internal powers influence sweeping changes across the medical segment. Externally, medical providers are responding to far-flung changes pertained to accountable care including health regulatory reforms, patient census demographics and shift from fee for medical service to value based medicine. Internally, monumental generational changes in the employee force are leading leadership transitions and challenging workforce at all levels. Organizational culture is one of the most important, still, fugacious components for assuring continued success during this time of significant change. Strong organization culture can be the glue that keeps workforce together through a range of challenges, companies which identify and nutrify culture make a powerful force for organizational leadership, retention and stability. Nowadays, leading medical care players, identified bui...

Climate Change and Health Matters: Climate change is a more serious issue than anticipated by most of us. This issue had been ignored for ages and now the situation is demanding action from each one of us, else the generation to come will curse their fore fathers for the damage they had done in the past. It is predicted that there would be extensive changes in world climate and the repercussions of these changes will be visible across the globe, irrespective of the physical boundaries set by nations or countries. It will not be just your neighbours problem, because the eventualities will be visible with in your courtyard and will have to be shared by you as well. The individual nano steps taken across the globe towards this issue is negligible in all sense considering the amount of irreparable damage that has already been done over the ages, when we had the industrial revolution in the history and the same taken forward by our fore fathers. Every giant leap by the human kin...

Magnetic opportunities for Indian Pharma : Indian medicine companies are presented with attractive growth opportunities because of consolidation of global generics, according to Moody’s Investors Service (American ratings, research, and risk analysis firm). Drug producers here exhibit stronger business profiles compared to global peers due to their geographic diversity and strong product pipeline for developed markets, states the firm’s latest report, “Indian Pharmaceutical Companies – A Deep Dive”. The report also states that the Indian drug makers may explore and benefit from some overseas Merger &acquisition (M&A) on the back of consolidation of global generics. Large promoter ownerships may dissuade M&A activity domestically, it adds. “The global pharmaceutical industry is undergoing consolidation, driven by a desire for product and pipeline diversity, scale and pricing power,” states the report. “Historical acquisitions have been small in the Indian p...

EFFECTIVE INDUCTION….IMPACT: Think about situation:   it’s your joining day with new employer and you are expecting that you might have an easy day of induction program and finding your feet. Deplorably, your new employer has not taken time to have induction for you as they are really busy on their assignments. You are directly assigned on the project and expected to manage things “on the hoof”. You have not been introduced to any of your team members or workgroup, what you will be doing that day or how to use your safety equipment. Every day new employees have horrible experiences (of first day) that do untold damage to the employer brand and will have direct impact for many other channels. In the crucial early stages of employment, a new employee will make important first notions about their role, their workgroup and the organization. A well planned or well handled induction program serves to set a positive tone and cut down the required time to settle in to new role, adj...

GENERIC SUBSTITUTION… Generic substitution is the practice of shifting from a prescribed originator medicine product to an interchangeable medicine that consisting the same active pharmaceutical ingredient-the strength, the same concentration, for the same route of administration. The generic medicine may differ in organoleptic characteristics, labeling and packaging patterns however because of these formulation differences, the generic drug players are required to submit additional paper work to drug regulatory authorities to prove that their product is manufactured in accordance with good manufacturing practices (cGMP) and is similar or as pure and stable as the branded medicine; are generally commercialized under the nonproprietary name or could be marketed as branded generics. This week our update covers the some of the most common questions that some patient asks about generic products are following: WHAT ARE GENERIC MEDICINES? A generic product is a similar product of...

LABORATORY ACCREDITATION: Laboratory accreditation keeps formal recognition to competent laboratories, thus providing ready solutions that means for business partners to find out and select reliable testing and calibration facilities for their needs. To maintain this recognition, the service providers re-evaluated regularly by the authorities to assure their continued compliance with set guidelines and procedures and go over that their standard of functioning being well-kept or maintained. The laboratories required to participate in relevant proficiency testing programs among reassessments, as further presentation of technical competence. Recognized facilities generally release calibration reports bearing the accreditation body’s symbol, as an indication of their accreditation. Sponsors are furthered to verify with laboratory as to what necessary measurements they are accredited for? And also for what ranges?? This data is clearly and explicitly stated in the laboratory’s s...

KNOW YOUR RIGHT PATH…! You got that new career opportunity with special effort and you are ready to make a positive touch at your new company however before you start, it is highly important for you have an elaborate, strong and systematic plan of action. Your further success relies on it. This week update provides our readers with few tips to ensure this new begin in your career start off in the right path. You have succeed the arduous interview process and successfully put down that new position. Starting up a new opportunity is shaking up however makes even the highly experienced professionals a little anxious in the new environment. You aware there are assignments to carry out and fresh relationships to build, however, most significantly you want to prove that you can get the job done. However before you get into new position consider this: The essential part to great begin at a new employer knows how to convert new career opportunities and challenges in to feting career ...

UV Protection..! Scientific laboratories are the most challenging places to work safely. This article alert you to a significant radiation risk that present in the laboratories – ultraviolet light (UV), most of us studied and remember that ultraviolet makes up a small band on the electromagnetic spectrum, that the sun is our largest source of ultraviolet. Perchance many of us work with ultraviolet light daily and are well aware in the science of electromagnetic radiation; however, this article will focus with a basic ultraviolet review. Ultraviolet is a form of nonionizing radiation light or is electromagnetic radiation with a wavelength shorter than that of visible light but longer than X-rays, observed within the electromagnetic spectrum between X-rays, visible light and is generally split up into 3 classes based upon wavelength : UV-A with a wavelength of 315 to 400 nanometre (nm) known as black light, UV-B with a wavelength from 280 to 314 nanometre known as eurytherma...

Meeting Efficiency: When official meetings in medical profession where participants don’t aware why they are, they can responsively become frustrated and neglectful; and if the top level failure to plan in advance or failure to provide clear protocols, well- purposed meetings can go without efficiency. This update brings about few tips for overturning the efficiency of medical set up meetings Begin with a clear Intention: Well purposed meetings will start with well specified goals. State emphatically and authoritatively the purpose of the meeting in the invitation so the attendees keen about what topics will be discussed through the meetings. Not only will this keep the meeting on track, it will push to come prepared with queries and possible reports by all participants. Invite the right Members: It’s common for initiators to regularly involve the same personalities to a variety of meetings. From now for future meetings, very keen to whom you are including in the meetin...