Apoptosis Signaling Pathway

Introduction to Apoptosis:

Since the mid of nineteenth century it has been indicated that necrobiosis or cell death plays a major role during physiological process of multicellular organism, especially during embryogenesis and metamorphosis. The concept of PCD (programmed cell death) was first came into picture in the year 1964, stating that cell death at the time of growth is not a surprising event but follows a sequence of preplanned or programmed step leading to locally and temporally defined self-destruction.

The term Apoptosis was coined in order to depict the morphological processes heading to controlled cellular self-destruction. It was 1st introduced in a publication by Kerr, Wyllie and Currie [Kerr, 1972]. The apoptotic way of cell death is an active and defined process that plays a major role in the development of multicellular organisms and also helps in regulation and maintenance of the cell populations in tissue upon physiological and pathological conditions.

Apoptosis: It can be defined as a type of cell death in which a cell uses specialized cellular machinery to kill itself; a cell suicide mechanism that enables metazoans to control cell number and eliminate cells that threaten the animal’s survival. The end result of apoptosis is cell death without inflammation of the surrounding tissue.

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