Technology that increase the efficiency of vaccines

TECHNOLOGY ENHANCING VACCINE EFFICIENCY:

It is a well known fact that, for any pharma companies the most crucial and challenging issue is inventing a technology that can enhance the activity of vaccines. A paper published in Journal vaccine, 2008, by a company called Cure Lab, Inc. a Massachusetts based biotechnology company developed a new methodology for anti-viral vaccination. This vaccination technology comprises of two main components: The 1st component comprises of vaccine antigen that should be in two patterns. One should be easily processed inside the organism’s cells by an intracellular “chopping machine” called proteosome, while other element is resistant to “chopping”. According to the research published in Journal Vaccine, both these forms of an antigen would be used in combination to elicit a much stronger immune response than either of them would be able to do alone.

With the invention of technology that could create a form of viral protein that could be easily processed inside the cell, made Dr. Petr Ilyinskii of Cure Lab along with his colleagues to think that they have achieved their goal. They also thought that a modified protein with altered structure would make a protein segments available for antigen presentation and therefore will act as strong immunogen. However, the bad news was waiting for his chance. Soon proteosomes degradable proteins were not considered as better vaccines when compared to their counterparts. Similar type of problems were encountered by other research groups who were dealing with the more or less similar kind of research work. These abortive attempts temporarily puts an end to great hopes for the future of vaccines development based on proteosomes degradation.

According to latest scientific report, Dr. Alex Shneider with his colleagues hypothesized that there are two mechanism that present a viral protein to the immune system. One needs peptide deduced from the antigen protein, while the other present the entire intact protein. Therefore, by developing a protein which could be rapidly degraded by the proteosome we can enhance this first mechanism, and make the other unaffected to chopping and good for the second mechanism.

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